Aim: This study aims to compare post-operative evaluation of locking and non-locking miniplates in mandibular fractures. Materials and Methods: The study consisted sample size of 40 patients non-comminuted fractures (40 fracture sites) were divided randomly but equally (single-blind control trial study) into two equal groups. Each group contains 20 patients (20 similar fracture sites in each group). Group 1 was treated with open reduction and internal fixation using 2.0 mm non-locking miniplates. Group 2 was treated using locking 2 mm miniplates. Results: Of 20 patients treated by conventional 2 mm miniplates, no any patients developed occlusal discrepancy, but one had post-operative mobility at fracture site, and one developed plate failure and subsequent infection, which was treated by removal of the plate under antibiotic coverage. One patient treated by three-dimensional plates had tooth damage. Conclusion: Based on the results of this original research concluded that the treatment of various mandibular fractures (parasymphysis, symphysis, and angle) with 2.0 mm locking plates provided three-dimensional stability, more stable configuration with lower meant element stresses and thus showed zero morbidity and was not associated with any major complications. The only probable limitations of locking plates were excessive implant material due to the extra vertical bars incorporated for countering the torque forces.